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1999 1
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Page 1
Association between genetic risk variants and glucose intolerance during pregnancy in north Indian women.
Arora GP, Almgren P, Brøns C, Thaman RG, Vaag AA, Groop L, Prasad RB. Arora GP, et al. BMC Med Genomics. 2018 Aug 8;11(1):64. doi: 10.1186/s12920-018-0380-8. BMC Med Genomics. 2018. PMID: 30089489 Free PMC article.
METHODS: Five thousand one hundred pregnant women of gestational age 24-28 weeks from Punjab were studied by a 75 g oral glucose tolerance test (OGTT). GDM was diagnosed by both WHO1999 and 2013 criteria. 79 single nucleotide polymorphisms (SNPs) previously associated with …
METHODS: Five thousand one hundred pregnant women of gestational age 24-28 weeks from Punjab were studied by a 75 g oral glucose tole …
Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function.
Renner S, Fehlings C, Herbach N, Hofmann A, von Waldthausen DC, Kessler B, Ulrichs K, Chodnevskaja I, Moskalenko V, Amselgruber W, Göke B, Pfeifer A, Wanke R, Wolf E. Renner S, et al. Diabetes. 2010 May;59(5):1228-38. doi: 10.2337/db09-0519. Epub 2010 Feb 25. Diabetes. 2010. PMID: 20185813 Free PMC article.
To evaluate the role of impaired GIP function in glucose homeostasis and development of the endocrine pancreas in a large animal model, we generated transgenic pigs expressing a dominant-negative GIP receptor (GIPR(dn)) in pancreatic islets. ...The insulinotropic ef …
To evaluate the role of impaired GIP function in glucose homeostasis and development of the endocrine pancreas in a large animal mode …
Glucoregulatory, endocrine and morphological effects of [P5K]hymenochirin-1B in mice with diet-induced glucose intolerance and insulin resistance.
Owolabi BO, Ojo OO, Srinivasan DK, Conlon JM, Flatt PR, Abdel-Wahab YH. Owolabi BO, et al. Naunyn Schmiedebergs Arch Pharmacol. 2016 Jul;389(7):769-81. doi: 10.1007/s00210-016-1243-5. Epub 2016 Apr 12. Naunyn Schmiedebergs Arch Pharmacol. 2016. PMID: 27068334
This study examines the effects of 28-day administration of a more potent analogue [P5K]hymenochirin-1B ([P5K]hym-1B) (75 nmol.kg(-1) body weight) to high-fat-fed mice with obesity, glucose intolerance and insulin resistance. Treatment with [P5K]hym-1B significantly …
This study examines the effects of 28-day administration of a more potent analogue [P5K]hymenochirin-1B ([P5K]hym-1B) (75 nmol.kg(-1) body w …
GIP mediates the incretin effect and glucose tolerance by dual actions on alpha cells and beta cells.
El K, Gray SM, Capozzi ME, Knuth ER, Jin E, Svendsen B, Clifford A, Brown JL, Encisco SE, Chazotte BM, Sloop KW, Nunez DJ, Merrins MJ, D'Alessio DA, Campbell JE. El K, et al. Sci Adv. 2021 Mar 12;7(11):eabf1948. doi: 10.1126/sciadv.abf1948. Print 2021 Mar. Sci Adv. 2021. PMID: 33712466 Free PMC article.
Glucose-dependent insulinotropic polypeptide (GIP) communicates nutrient intake from the gut to islets, enabling optimal levels of insulin secretion via the GIP receptor (GIPR) on beta cells. ...Moreover, we demonstrate that GIP activity in alpha cells contributes t …
Glucose-dependent insulinotropic polypeptide (GIP) communicates nutrient intake from the gut to islets, enabling optimal levels of in …
Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity.
Deshmukh HA, Madsen AL, Viñuela A, Have CT, Grarup N, Tura A, Mahajan A, Heggie AJ, Koivula RW, De Masi F, Tsirigos KK, Linneberg A, Drivsholm T, Pedersen O, Sørensen TIA, Astrup A, Gjesing AAP, Pavo I, Wood AR, Ruetten H, Jones AG, Koopman ADM, Cederberg H, Rutters F, Ridderstrale M, Laakso M, McCarthy MI, Frayling TM, Ferrannini E, Franks PW, Pearson ER, Mari A, Hansen T, Walker M. Deshmukh HA, et al. J Clin Endocrinol Metab. 2021 Jan 1;106(1):80-90. doi: 10.1210/clinem/dgaa653. J Clin Endocrinol Metab. 2021. PMID: 32944759 Free PMC article.
CONTEXT: Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. ...After correction for multiple testing, glycemi …
CONTEXT: Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a k …
Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob mice.
Shimazu-Kuwahara S, Harada N, Yamane S, Joo E, Sankoda A, Kieffer TJ, Inagaki N. Shimazu-Kuwahara S, et al. Mol Metab. 2017 Jan 19;6(3):288-294. doi: 10.1016/j.molmet.2017.01.006. eCollection 2017 Mar. Mol Metab. 2017. PMID: 28271035 Free PMC article.
OBJECTIVE: Glucose-dependent insulinotropic polypeptide (GIP) is released during meals and promotes nutrient uptake and storage. ...Insulin levels were equivalently elevated in both Lep(ob/ob)/GIP(+/+) and Lep(ob/ob)/GIP(gfp/gfp) mice compared to controls at 8 weeks of age …
OBJECTIVE: Glucose-dependent insulinotropic polypeptide (GIP) is released during meals and promotes nutrient uptake and storage. ...I …
Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes.
Gault VA, Irwin N, Green BD, McCluskey JT, Greer B, Bailey CJ, Harriott P, O'harte FP, Flatt PR. Gault VA, et al. Diabetes. 2005 Aug;54(8):2436-46. doi: 10.2337/diabetes.54.8.2436. Diabetes. 2005. PMID: 16046312

GIP-R ablation also significantly lowered overall plasma glucose (1.4-fold; P < 0.05) and insulin (1.5-fold; P < 0.05) responses to feeding. ...These comprehensive beneficial effects of (Pro3)GIP were reversed 9 days after cessation of treatment and were independent

…

GIP-R ablation also significantly lowered overall plasma glucose (1.4-fold; P < 0.05) and insulin (1.5-fold; P < 0.05) response

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Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice.
Miyawaki K, Yamada Y, Yano H, Niwa H, Ban N, Ihara Y, Kubota A, Fujimoto S, Kajikawa M, Kuroe A, Tsuda K, Hashimoto H, Yamashita T, Jomori T, Tashiro F, Miyazaki J, Seino Y. Miyawaki K, et al. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14843-7. doi: 10.1073/pnas.96.26.14843. Proc Natl Acad Sci U S A. 1999. PMID: 10611300 Free PMC article.
GIPR-/- mice have higher blood glucose levels with impaired initial insulin response after oral glucose load. Although blood glucose levels after meal ingestion are not increased by high-fat diet in GIPR+/+ mice because of compensatory higher in …
GIPR-/- mice have higher blood glucose levels with impaired initial insulin response after oral glucose load. Although …
Association of variants in gastric inhibitory polypeptide receptor gene with impaired glucose homeostasis in obese children and adolescents from Berlin.
Sauber J, Grothe J, Behm M, Scherag A, Grallert H, Illig T, Hinney A, Hebebrand J, Wiegand S, Grüters A, Krude H, Biebermann H. Sauber J, et al. Eur J Endocrinol. 2010 Aug;163(2):259-64. doi: 10.1530/EJE-10-0444. Epub 2010 Jun 1. Eur J Endocrinol. 2010. PMID: 20516203
OBJECTIVE: In the past 20 years, obesity has become a major health problem due to associated diseases like type 2 diabetes mellitus. The gastric inhibitory polypeptide receptor (GIPR) modulates body weight and glucose homeostasis and, therefore, represents an intere …
OBJECTIVE: In the past 20 years, obesity has become a major health problem due to associated diseases like type 2 diabetes mellitus. The gas …
Vaccination against GIP for the treatment of obesity.
Fulurija A, Lutz TA, Sladko K, Osto M, Wielinga PY, Bachmann MF, Saudan P. Fulurija A, et al. PLoS One. 2008 Sep 9;3(9):e3163. doi: 10.1371/journal.pone.0003163. PLoS One. 2008. PMID: 18779862 Free PMC article.
In fact GIP receptor-deficient mice (GIPR(-/-)) were shown to be completely protected from diet-induced obesity. ...Importantly, despite the incretin action of GIP, VLP-GIP-treated mice did not show signs of glucose intolerance. CONCLUSIONS/SIGNIFICANCE: This …
In fact GIP receptor-deficient mice (GIPR(-/-)) were shown to be completely protected from diet-induced obesity. ...Importantly, desp …
15 results